Biological markers of amyloid β-related mechanisms in Alzheimer's disease
نویسندگان
چکیده
منابع مشابه
Molecular mechanisms initiating amyloid β-fibril formation in Alzheimer’s disease
decline characteristic of AD. Therefore, a detailed knowledge of Aβ assembly is crucial for the development of new therapeutic approaches designed to prevent fibril formation and/or to dissociate existing fibrils. Yet, our understanding of the molecular mechanisms underlying the initiation of Aβ fibrillogenesis remains very incomplete. Amyloid β-peptide is produced by specific endoproteolytic c...
متن کاملThe role of β-amyloid in alzheimer's disease-related neurodegeneration.
Editor's Note: These short, critical reviews of recent papers in the Journal, written exclusively by graduate students or postdoctoral fellows, are intended to summarize the important findings of the paper and provide additional insight and commentary. For more information on the format and purpose of the Journal Club, please see It is currently estimated that over 35 million people worldwide h...
متن کاملAmyloid-β and Astrocytes Interplay in Amyloid-β Related Disorders
Amyloid-β (Aβ) pathology is known to promote chronic inflammatory responses in the brain. It was thought previously that Aβ is only associated with Alzheimer's disease and Down syndrome. However, studies have shown its involvement in many other neurological disorders. The role of astrocytes in handling the excess levels of Aβ has been highlighted in the literature. Astrocytes have a distinctive...
متن کاملVarenicline Ameliorates Learning and Memory Deficits in Amyloid β(25–35) Rat Model of Alzheimer’s Disease
Introduction: Alzheimer’s disease (AD) is a enfeeble neurodegenerative disorder characterized by increased β-amyloid (Aβ) deposition and neuronal dysfunction leading to impaired learning and recall. Among proposed risk factors, impaired cholinergic transmission is a main cause for incidence of disease. Methods: In the present study, effects of the intracerebroventricularly administration of an ...
متن کاملSynthesis and biological assessment of 2-hydroxyiminoethanones as anti-inflammatory and β-amyloid aggregation inhibitors
Alzheimer’s disease (AD) is a neuroinflammatory based pathologic state in which β-amyloid aggregates are a major devastating agents. In this study, a series of 2-hydroxyiminoethanones were synthesized and evaluated as anti-inflammatory in carrageenan and formalin tests and inhibitors of β-amyloid aggregation. Compounds 1-10b were synthesized through a two-step reaction. Results: Compounds 1-5b ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Experimental Neurology
سال: 2010
ISSN: 0014-4886
DOI: 10.1016/j.expneurol.2009.09.024